Publications of the group 

2023

The AE4 transporter mediates kidney acid-base sensing. Vitzthum H, Koch M, Eckermann L, Svendsen SL, Berg P, Hübner CA, Wagner CA, Leipziger J, Meyer-Schwesinger C, Ehmke H. Nat Commun. 2023 May 26;14(1):3051.

Synuclein α accumulation mediates podocyte injury in Fabry nephropathy. Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig AK, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. J Clin Invest. 2023 Apr 4:e157782

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis. Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C. Nat Commun. 2023 Apr 28;14(1):2453.

Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function. Bouron A, Aubry L, Loreth D, Fauvarque MO, Meyer-Schwesinger C. Front Cell Neurosci. 2023 Mar 23;17:1149954.

CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12. Paust HJ, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel JH, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel UO, Steinmetz OM, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer MT, Hoxha E, Stahl RAK, Huber TB, Bonn S, Meyer-Schwesinger C, Wiech T, Turner JE, Becher B, Krebs CF, Panzer U. Sci Transl Med. 2023 Mar 15;15(687):eadd6137.

Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis. Mueller A, Zhao Y, Cicek H, Paust HJ, Sivayoganathan A, Linke A, Wegscheid C, Wiech T, Huber TB, Meyer-Schwesinger C, Bonn S, Prinz I, Panzer U, Tiegs G, Krebs CF, Neumann K. J Am Soc Nephrol. 2023 Mar 13.

Pathogenicity of human PLA2R1-antibodies in minipigs: a pilot study. Reinhard L, Wiech T, Reitmeier A, Lasse M, Machalitza M, Heumann A, Ferru N, Loreth D, Schröder M.-L., Hutzfeldt A, Stahl FR, Peine S, Gröne H.-J., Meyer-Schwesinger C, Rinschen MM, Stahl RAK, Hoxha E. J Am Soc Nephrol. 2023 Mar 1;34(3):369-373.

Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice. Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G. Kidney Int. 2023 Feb;103(2):297-303.

The classical pathway triggers pathogenic complement activation in membranous nephropathy. Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner SMS, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel PF, Hopfer H, Puelles VG, Panzer U, Huber TB, Wiech T, Tomas NM. Nat Commun. 2023 Jan 28;14(1):473.

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy. Liu S, Zhao Y, Lu S, Zhang T, Lindenmeyer MT, Nair V, Gies SE, Wu G, Nelson RG, Czogalla J, Aypek H, Zielinski S, Liao Z, Schaper M, Fermin D, Cohen CD, Delic D, Krebs CF, Grahammer F, Wiech T, Kretzler M, Meyer-Schwesinger C, Bonn S, Huber TB. Genome Med. 2023 Jan 10;15(1):2.

Kidney-resident innate-like memory gdT cells control chronic Staphylococcus aureus infection in mice. Bertram T, Reimers D, Lory NC, Schmitdt C, Schmid J, Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nunez S, Rosemblatt M, Bono MR, Gagliani N, Sandrock I, Panzer U, Krebs CF, Meyer-Schwesinger C, Prinz I, Mittrücker HW. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2210490120.

2022

Antigen cross-presentation by murine proximal tubular epithelial cells induces cytotoxic and inflammatory CD8+ T cells. Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz, OM, Diehl L, Tiegs G, Neumann K. Cells. 2022 Apr 30;11(9):1510.

Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria. Woznowski MP, Potthoff SA, Königshausen E, Haase R, Hoch H, Meyer-Schwesinger C, Wiech T, Stegbauer J, Rump LC, Sellin L, Quack I. J Mol Med (Berl). 2022 May;100(5):781-795.

The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice. Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen MM, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J. Kidney Int. 2022 Mar 7:S0085-2538(22)00175-2.

Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease. Meyer-Schwesinger C, Seipold L, Saftig P. Biochim Biophys Acta Mol Cell Res. 2022 Mar;1869(3):119165.

2021

The intertwining of autophagy and the ubiquitin proteasome system in podocyte (patho)physiology. Heintz L,  Meyer-Schwesinger C. Cell Physiol Biochem. 2021 Sep 15;55(S4):68-95.

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. Schneider E, Winzer R, Rissiek A, Ricklefs I,  Meyer-Schwesinger C, Ricklefs FL, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller CE, Gagliani N, Tolosa E Nat Commun. 2021 Oct 8;12(1):5911

Tripartite separation of glomerular cell-types and proteomes from reporter-free mice. Hatje FA, Wedekind U, Sachs W, Loreth D, Reichelt J, Demir F, Kosub C, Heintz L, Tomas NM, Huber TB, Skuza S, Sachs M, Zielinski S, Rinschen MM*,  Meyer-Schwesinger  C*. J Am Soc Nephrol. 2021 Sep;32(9):2175-2193

ADP-ribosylation regulates the signaling function of IFN-γ. Menzel S, Koudelka T, Rissiek B, Haag F, Meyer-Schwesinger C, Tholey A, Koch-Nolte F. Front Immunol. 2021 Mar 8;12:642545.

ADAM10-mediated ectodomain shedding is an essential driver of podocyte damage Sachs M*, Wetzel S*, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P* and Meyer-Schwesinger C*. J Am Soc Nephrol. 2021 Jun 1;32(6):1389-1408.

Lysosome function in glomerular health and disease. Meyer-Schwesinger C. Cell Tissue Res. 2021 Aug;385(2):371-392.

2020

The ins-and-outs of podocyte lipid metabolism. Meyer-Schwesinger C. Kidney Int. 2020 Nov;98(5):1087-1090

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease. Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW. Sci Immunol. 2020 Aug 7;5(50):eaba4163. 

Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria Sachs W, Sachs M, Krüger E, Zielinski S, Kretz, Huber TB, Baranowsky A, Westermann LM, Voltolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S* and Meyer-Schwesinger C*. J Am Soc Nephrol. 2020 Aug, 31(8):1796-1814 

A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients. Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G. Kidney Int. 2020 May;97(5):913-919

B6.Rag1 knockout mice generated at the Jackson laboratory in 2009 show a robust wild-type hypertensive phenotype in response to Ang II (Angiotensin II). Seniuk A, Thiele JL, Stubbe A, Oser P, Rosendahl A, Bode M, Meyer-Schwesinger C, Wenzel UO, Ehmke H. Hypertension. 2020 Apr;75(4):1110-1116.

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis Miesen L, Eymael J, Loeven MA, Willemsen B, Bakker-von Bebber M, Mooren F, Meyer-Schwesinger C, Dijkman H, Wetzels J, Jansen J, van der Flag J, Smeets B. Sci Rep. 2020 May 22;10(1):8580

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H Muehlig AK, Keir LS, Abt JC, Heidelbach HS, Horton RH, Welsh GI, Meyer-Schwesinger C, Licht C, Coward R, Fester L, Saleem MA, Oh J. Front Immunol. 2020 Aug 14;11:1833

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy. Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE. Kidney Int. 2020 May 21:S0085-2538(20)30537-8.

Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes. Hendrickx G, Danyukova T, Baranowsky A, Rolvien T, Angermann A, Schweizer M, Keller J, Schröder J, Meyer-Schwesinger C, Muschol N, Paganini C, Rossi A, Amling M, Pohl S, Schinke T. Hum Mol Genet. 2020 Mar 27;29(5):803-816.

2019

Glomerular cell biology and podocytopathies. Meyer-Schwesinger C, Huber TB. Brenner + Rector's The Kidney 2019 11th Edition USA, Philadelphia: Elsevier Inc., Chapter 4, p115-132 

Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules. Reinicke AT, Raczkowski F, Mühlig M, Schmucker P, Lischke T, Reichelt J, Schneider E, Zielinski S, Sachs M, Jurack E, Tolosa E, Kurts C, Mittrücker HW, Meyer-Schwesinger C. J Immunol. 2019 Oct 1;203(7):1730-1742. 

The ubiquitin-proteasome system in kidney physiology and disease. Meyer-Schwesinger C. Nat Rev Nephrol. 2019 Jul;15(7):393-411. 

An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome? Meyer-Schwesinger C. Kidney Int. 2019 May;95(5):1015-1017.

Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. Herwig J*, Skuza S*, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C. J Am Soc Nephrol. 2019 May;30(5):824-839.

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks. Reinicke AT*, Laban K*, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F*, Meyer-Schwesinger C*. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7963-7972.

Protecting the kidney against autoimmunity and inflammation. Kurts C, Meyer-Schwesinger C. Nat Rev Nephrol. 2019 Feb;15(2):66-68.

Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses. Breda PC, Wiech T,  Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F77-F89

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins. Königshausen E, Potthoff SA, Haase R, Meyer-Schwesinger C, Kaufmann E, Rump LC, Stegbauer J, Sellin L, Quack I, Woznowski M. J Vis Exp. 2019 Jan 18;(143).

Endogenous IL-22 is dispensable for experimental glomerulonephritis. Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JE. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F712-F722.

2018

Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney. Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop JH, Wiech T, Wenzel UO, Sachs M, Reinicke AT, Stahl RAK, Meyer-Schwesinger C. Kidney Int. 2018 Jan;93(1):110-127.

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity. Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T. Cell Rep. 2018 Sep 11;24(11):2946-2956.

The chemokine receptor CX 3CR1 reduces renal injury in mice with angiotensin II-induced hypertension. Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust HJ, Huber TB, Stahl RAK, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UO. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1526-F1535.

Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition. Kumar V, Vashistha H, Lan X, Chandel N, Ayasolla K, Shoshtari SSM, Aslam R, Paliwal N, Abbruscato F, Mikulak J, Popik W, Atta MG, Chander PN, Malhotra A, Meyer-Schwesinger C, Skorecki K, Singhal PC. Am J Pathol. 2018 Nov;188(11):2508-2528.

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott RP, Blobel CP. Angiogenesis. 2018 May;21(2):335-347

2017

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy. Tomas NM*, Meyer-Schwesinger C*, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK. J Am Soc Nephrol. 2017 Nov;28(11):3262-3277.

A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease. Haase R, Potthoff SA, Meyer-Schwesinger C, Frosch C, Wiech T, Panzer U, Königshausen E, Stegbauer J, Sellin L, Rump LC, Quack I, Woznowski M. PLoS One. 2017 Jun 12;12(6):e0179217.

IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis. Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RAK, Panzer U, Turner JE. J Am Soc Nephrol. 2017 Jul;28(7):2068-2080. 

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. Hoxha E, Beck LH Jr, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA. J Am Soc Nephrol. 2017 Feb;28(2):520-531.

2016

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. Danquah W*, Meyer-Schwesinger C*, Rissiek B*, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F. Sci Transl Med. 2016 Nov 23;8(366):366ra162.

Autoantibodies against thrombospondin type-1 domain-containing 7A induce membranous nephropathy Tomas NM*, Hoxha E*, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C*, Stahl RAK*. J Clin Invest. 2016 Jul 1;126(7):2519-32.

Autoimmune renal disease is exacerbated by S1P-Receptor-1-Dependent intestinal Th17 cell migration to the kidney. Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RAK, Huber S, Turner JE, Panzer U. Immunity. 2016 Nov 15;45(5):1078-1092. 

A Mechanism for Cancer-Associated Membranous Nephropathy. Hoxha E, Wiech T, Stahl P R, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA. N Engl J Med. 2016 May 19;374(20):1995-6.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO. Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1356-65.

Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy. Grau V, Zeuschner P, Immenschuh S, Bockmeyer CL, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker JU. Transplantation. 2016 May;100(5):1004-14.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN. Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U. J Am Soc Nephrol. 2016 Jul;27(7):1933-42.

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus. Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM. Kidney Int. 2016 Jan;89(1):158-66.

The Role of Renal Progenitors in Renal Regeneration. Meyer-Schwesinger C. Nephron. 2016;132(2):101-9.

2015

MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype. Kietzmann L*, Guhr SS*, Meyer TN, Ni L, Sachs M, Panzer U, Stahl RA, Saleem MA, Kerjaschki D, Gebeshuber CA* and Meyer-Schwesinger C*. J Am Soc Nephrol. 2015 Jun;26(6):1389-401.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. Meyer-Schwesinger C, Lambeau G, Stahl RA. N Engl J Med. 2015 Mar 12;372(11):1074-5.

TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker HW. J Pathol. 2015 Sep;237(1):62-71.

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation. Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Koch-Nolte F, Mittrücker HW. PLoS One. 2015 May 4;10(5):e0126007.

Glomerulopathy induced by immunization with a peptide derived from the goodpasture antigen α3IV-NC1. Hopfer H, Hünemörder S, Treder J, Turner JE, Paust HJ, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker HW. J Immunol. 2015 Apr 15;194(8):3646-55.

CXCL5 drives neutrophil recruitment in TH17-mediated GN. Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U. J Am Soc Nephrol. 2015 Jan;26(1):55-66.

2014

UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. Lohmann, F., Meyer, TN., Sachs, M., Sievert, H., Lindenmeyer, MT., Wiech, T., Cohen, CD., Balabanov, S., Stahl, RA, Meyer-Schwesinger, C. Biochim Biophys Acta. 2014 Jul;1842(7):945-58.

UPS alterations in persistent but not reversible proteinuric diseases. Beeken M*, Lindenmeyer MT*, Blattner SM*, Radón V*, Oh J, Meyer TN, Hildebrand D, Schlüter H, Reinicke AT, Knop JH, Vivekanandan-Giri A, Münster S, Sachs M, Wiech T, Pennathur S, Cohen CD, Kretzler M, Stahl RA, Meyer-Schwesinger C. J Am Soc Nephrol. 2014 Nov;25(11):2511-25.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. Tomas NM*, Beck LH Jr*, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. N Engl J Med. 2014 Dec 11;371(24):2277-87.

Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice. Lehners A, Lange S, Niemann G, Rosendahl A, Meyer-Schwesinger C, Oh J, Stahl R, Ehmke H, Benndorf R, Klinke A, Baldus S, Wenzel UO. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F407-17

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis. Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner J 3rd, Faé KC, Arrey F, Kuhlmann S, Bandermann S, Loewe D, Mollenkopf HJ, Vogelzang A, Meyer-Schwesinger C, Mittrücker HW, McEwen G, Kaufmann SH. J Clin Invest. 2014 Mar;124(3):1268-82.

Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium. Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR. Cell. 2014 Jan 30;156(3):456-68.

B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis. Kluger M. A., Ostmann  A., Luig  M., Meyer M. C ., Goerke B., Paust H.-J., Meyer-Schwesinger C., Stahl R. A. K., Panzer U., Tiegs G., Steinmetz O. M. Eur J Immunol. 2014 Mar;44(3):683-93.

Deficiency of the Interleukin 17/23 Axis Accelerates Renal Injury in Mice With Deoxycorticosterone Acetate+Angiotensin II-Induced Hypertension. Krebs CF, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl RA, Benndorf RA, Velden J, Paust HJ, Panzer U, Ehmke H, Wenzel UO. Hypertension. 2014 Mar;63(3):565-71.

2013

Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1. Thies B*, Meyer-Schwesinger C*, Lamp J, Schweizer M, Koeller DM, Ullrich K, Braulke T, Mühlhausen C. Biochim Biophys Acta. 2013 Oct;1832(10):1463-72.

The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation. Guhr SS, Sachs M, Wegner A, Becker JU, Meyer TN, Kietzmann L, Schlossarek S, Carrier L, Braig M, Jat PS, Stahl RA, Meyer-Schwesinger C. Kidney Int. 2013 Sep;84(3):532-44.

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Sosna J., Voigt S., Mathieu S., Kabelitz D., Trad A., Janssen O., Meyer-Schwesinger C., Schütze S., Adam D. Cell Commun Signal. 2013 Oct 3;11(1):76.

Prognostic relevance of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients. Schröder C., Milde-Langosch K., Gebauer F., Schmid K., Müller V., Wirtz R.M., Meyer-Schwesinger C., Schlüter H., Sauter G. and Schumacher U. J Cancer Res Clin Oncol. 2013 Oct;139(10):1745-55.

Micro-RNA-155 drives T H17 immune response and tissue injury in experimental crescentic glomerulonephritis. Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U. J Am Soc Nephrol. 2013 Dec;24(12):1955-65.

Mouse models of membranous nephropathy: the road less travelled by. Borza DB, Zhang JJ, Beck LH Jr, Meyer-Schwesinger C, Luo W. Am J Clin Exp Immunol. 2013 Jun 15;2(2):135-45

2012

Rho-kinase inhibition prevents proteinuria in immune-complex mediated anti-podocyte nephritis. Meyer-Schwesinger C, Dehde S, Sachs M, Mathey S, Arefi K, Gatzemeier S, Balabanov S, Becker JU, Thaiss F, Meyer TN. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1015-25.

Characterization of the renal CD4(+) T-cell response in experimental autoimmune glomerulonephritis. Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker HW. Kidney Int. 2012 Jul;82(1):60-71. 

IL-17A Production by Renal γδ T Cells Promotes Kidney Injury in Crescentic GN. Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U. J Am Soc Nephrol. 2012 Sep;23(9):1486-95.

2011

Nephrotic Syndrome and Subepithelial Deposits in a Mouse Model of Immune-Mediated Anti-Podocyte Glomerulonephritis. Meyer-Schwesinger C, Dehde S, Klug P, Becker JU, Mathey S, Arefi K, Balabanov S, Venz S, Endlich KH, Pekna M, Gessner E, Thaiss F, Meyer TN., J Immunol. 2011 Sep 15;187(6):3218-29.

Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) Activity Induces Polyubiquitin Accumulation in Podocytes and Increases Proteinuria in Rat Membranous Nephropathy. Meyer-Schwesinger C*, Meyer TN*, Sievert H, Hoxha E, Sachs M, Klupp EM, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl RAK. Am J Pathol. 2011 May;178(5):2044-57.

Bone marrow-derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats. Meyer-Schwesinger C, Lange C, Bröcker V, Andina Agustian P, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Büsche G, Kreipe H, Thaiss F, Becker JU. Am J Pathol. 2011 Feb;178(2):494-9.

Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation. Ummanni R, Jost E, Braig M, Lohmann F, Mundt F, Barett C, Schlomm T, Sauter G, Senff T, Bokemeyer C, Sültmann H, Meyer-Schwesinger C, Brümmendorf TH, Balabanov S. Mol Cancer. 2011 Oct 14;10:129.

2010

CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. Tossidou I, Teng B, Drobot L, Meyer-Schwesinger C, Worthmann K, Haller H, Schiffer M. J Biol Chem. 2010 Aug 13;285(33):25285-95. 

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB. J Clin Invest. 2010 Apr 1;120(4):1084-96.

The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1330-41; Erratum in: Am J Physiol Renal Physiol. 2010 May;298(5):F1285.

2009

Rho-kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NFkB p65 signaling. Meyer-Schwesinger C, Dehde S, von Ruffer C, Gatzemeier S, Klug P, Wenzel UO, Stahl RA, Thaiss F, Meyer TN. Am J Physiol Renal Physiol. 2009 May;296(5):F1088-99.

A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies. Meyer-Schwesinger C, Meyer TN, Münster S, Klug P, Saleem M, Helmchen U, Stahl RA. J Pathol. 2009 Feb;217(3):452-64.

The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Shah MM*, Tee JB*, Meyer T*, Meyer-Schwesinger C*, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1330-41..

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U. J Immunol. 2009 Oct 1;183(7):4693-704.

Alterations of the podocyte proteome in response to high glucose concentrations. Schordan S, Schordan E, Endlich N, Lindenmeyer MT, Meyer-Schwesinger C, Meyer TN, Giebel J, Cohen CD, Endlich K, Maurer MH. Proteomics. 2009 Oct;9(19):4519-28.

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier. Pawar RD, Castrezana-Lopez L, Allam R, Kulkarni OP, Segerer S, Radomska E, Meyer TN, Schwesinger CM, Akis N, Gröne HJ, Anders HJ. Immunology. 2009 Sep;128(1 Suppl):e206-21. 

Resolution of renal inflammation: A new role for NF-kappa B1 (p50) in inflammatory kidney diseases. Panzer U, Steinmetz OM, Turner JE, Meyer-Schwesinger C, von Ruffer C, Meyer TN, Zahner G, Gómez-Guerrero C, Schmid RM, Helmchen U, Moeckel GW, Wolf G, Stahl RA, Thaiss F. Am J Physiol Renal Physiol. 2009 Aug;297(2):F429-39.

Lack of Type VIII Collagen in Mice Ameliorates Diabetic Nephropathy. Hopfer U, Hopfer H, Meyer-Schwesinger C, Loeffler I, Fukai N, Olsen BR, Stahl RA, Wolf G. Diabetes. 2009 Jul;58(7):1672-81.

Kidney dendritic cell activation links immune-mediated glomerular injury with tubulointerstitial immunopathology. Heymann F, Meyer-Schwesinger C, Hamilton-Williams EE, Hammerich L, Panzer U, Kaden S, Quaggin SE, Floege J, Gröne HJ, Kurts C. J Clin Invest. 2009 May;119(5):1286-97.

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl RA, Böger RH, Wenzel UO. Kidney Int. 2009 May;75(10):1039-49.

2008

CCR5 deficiency aggravates crescentic glomerulonephritis in mice. Turner JE, Paust HJ, Steinmetz OM, Peters A, Meyer-Schwesinger C, Fehr S, Heymann F, Helmchen U, Horuk R, Wenzel UO, Kurts C, Mittrücker HW, Stahl RAK, Panzer U. J Immunol. 2008 Nov 1;181(9):6546-56. 

Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats. Krebs C, Weber M, Steinmetz O, Meyer-Schwesinger C, Stahl RAK, Danser AHJ, I.M. Garrelds IM, van Goor H, Nguyen G, Müller D, Wenzel UO. Kidney Int. 2008 Sep;74(6):823-4.

Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II. Kirchhoff F, Krebs C, Abdulhag U, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers KF, Wolf G, Stahl RA, Wenzel U. Kidney Int. 2008 Mar;73(5):643-50.

2007

A new mouse model of immune mediated podocyte injury. Meyer TN, Meyer-Schwesinger C, Wahlefeld J, Dehde S, Becker JU, Kerjashki D, Stahl RA, Thaiss F. Kidney Int. 2007 Oct;72(7):841-52. 

A pitfall of glomerular sieving: profibrotic and matrix proteins derive from the Bowman's capsule and not the glomerular tuft in rats with renovascular hypertension. Steinmetz OM, Panzer U, Fehr S, Meyer-Schwesinger C, Stahl RA, Wenzel UO. Nephrol Dial Transplant. 2007 Oct;22(10):3055-60. 

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Krebs C, Hamming I, Sadaghiani S, Steinmetz OM, Meyer-Schwesinger C, Fehr S, Stahl RA, Garrelds IM, Danser AH, van Goor H, Contrepas A, Nguyen G, Wenzel U. Kidney Int. 2007 Sep;72(6):725-30. 

The chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner J, Zahner G, Reichel F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RAK. J Am Soc Nephrol, 2007 Jul;18(7):2071-84. 

Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Steinmetz OM, Sadaghiani S, Panzer U, Krebs C, Meyer-Schwesinger C, Streichert T, Fehr S, Hamming I, van Goor H, Stahl RA, Wenzel U. Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87.

2006

Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Meyer TN*, Schwesinger C*, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush KT, Nigam SK. Differentiation. 2006 Dec;74(9-10):638-47.

Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation. Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW. Biochem J. 2006 Nov 1;399(3):415-25.

2004

Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Meyer TN*, Schwesinger C*, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Dev Biol. 2004 Nov 1;275(1):44-67.

Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. Dev Biol. 2004 Aug 15;272(2):310-27.

TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK. Dev Biol. 2004 Feb 15;266(2):285-98.

2003

Ga12 regulates epithelial cell junctions through Src tyrosine kinases. Meyer TN, Hunt J, Schwesinger C, Denker BM. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1281-93.

2002

A strategy for in vitro propagation of rat nephrons. Steer DL, Bush KT, Meyer TN, Schwesinger C, Nigam SK. Kidney Int. 2002 Dec;62(6):1958-65.

Zonula Occludens-1 is a scaffolding protein for signaling molecules. G(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells. Meyer TN, Schwesinger C, Denker BM. J Biol Chem. 2002 Jul 12;277(28):24855-8.

2001

Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium.  Schwesinger C, Yee C, Rohan RM, Joussen AM, Fernandez A, Meyer TN, Poulaki V, Ma JJ, Redmond TM, Liu S, Adamis AP, D'Amato RJ. Am J Pathol. 2001 Mar;158(3):1161-72.

Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity. Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK. J Biol Chem. 2001 Jun 22;276(25):22048-55.

Angiogenic potential of prostate carcinoma cells overexpressing bcl-2. Fernandez A, Udagawa T, Schwesinger C, Beecken W, Achilles-Gerte E, McDonnell T, D'Amato R. J Natl Cancer Inst. 2001 Feb 7;93(3):208-13.